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Narendra Singh¹, Ramesh Singh², Manjulika Shukla³

¹Department of Chemistry, Indian Institute of Technology, Kanpur, Uttar Pradesh 208016, India.

ACS Infectious Diseases

|August 14, 2020

Abstract:

Stimuli-responsive self-destructing soft structures serve as versatile hosts for the encapsulation of guest molecules. A new paradigm for H₂S-responsive structures, based on a modified tripeptide construct, is presented along with microscopy evidence of its time-dependent rupture. As a medicinally interesting application, we employed these commercial antibiotic-loaded soft structures for successful drug release and inhibition of clinically relevant, drug-susceptible, and methicillin-resistant Staphylococcus aureus.

Keywords:

antibiotics drug delivery gasotransmitter hydrogen sulfide self-assembly

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