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Related Experiment Videos

Plasma expanders. An update.

G S Moss1, S A Gould

  • 1Department of Surgery, Michael Reese Hospital and Medical Center, Chicago, Illinois 60616.

American Journal of Surgery
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

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Isotonic crystalloid fluids effectively expand plasma volume. While colloids offer no proven benefit over crystalloids for resuscitation, hypertonic saline shows promise for smaller-volume resuscitation.

Area of Science:

  • Critical Care Medicine
  • Emergency Medicine
  • Fluid Resuscitation

Background:

  • Crystalloid solutions, such as 0.9% sodium chloride and Ringer's lactate, are commonly used plasma volume expanders.
  • Colloid solutions are frequently used in resuscitation, but evidence supporting their superiority over crystalloids is lacking.
  • The cost-effectiveness of colloids compared to crystalloids is also a consideration.

Purpose of the Study:

  • To review the literature on plasma volume expanders.
  • To compare the efficacy and benefits of crystalloid, colloid, and hypertonic saline solutions in resuscitation.
  • To evaluate the current indications for fresh frozen plasma.

Main Methods:

  • Literature review of studies on plasma volume expanders.

Related Experiment Videos

  • Analysis of evidence comparing crystalloid and colloid solutions in resuscitation.
  • Assessment of emerging fluid therapies, including hypertonic saline.
  • Consideration of National Institute of Health consensus on fresh frozen plasma use.

    • Main Results:

    • Isotonic crystalloids are effective plasma volume expanders.
    • No significant evidence supports the benefit of colloid solutions over crystalloid solutions in resuscitation.
    • Hypertonic saline solution is under investigation for its potential to achieve effective resuscitation with smaller fluid volumes, potentially reducing weight gain and edema.
    • Fresh frozen plasma is not indicated for use as a volume expander.

    Conclusions:

    • Isotonic crystalloids are a cost-effective and effective choice for plasma volume expansion.
    • Current evidence does not support the routine use of colloid solutions over crystalloids in resuscitation.
    • Hypertonic saline warrants further investigation as a resuscitation fluid.
    • Fresh frozen plasma has specific indications unrelated to volume expansion.