Related Experiment Video
Updated: Dec 12, 2025

Combining Fluidic Devices with Microscopy and Flow Cytometry to Study Microbial Transport in Porous Media Across Spatial Scales
Published on: November 25, 2020
Theoretical Framework of a Polydisperse Cell Filtration Model.
Yujun Wang1, Jian Gong1, Changsheng Su1
1Cummins Incorporated, 1900 McKinley Avenue, MC 50010, Columbus, Indiana 47201, United States.
A new discrete cell model accurately predicts filtration performance by incorporating pore size distribution, improving accuracy for ceramic filters and sub-100 nm particles.
Area of Science:
- Physical modeling
- Filtration science
- Materials science
Background:
- Filtration is a critical process requiring accurate physical models.
- Classical cell models oversimplify filtration media, leading to inaccurate performance predictions.
- Existing models struggle with polydisperse pore sizes and sub-100 nm particle filtration.
Purpose of the Study:
- To develop a discrete polydisperse cell model for high-fidelity filtration prediction.
- To derive a new equation for polydisperse cell efficiencies and medium efficiency.
- To validate the model's performance against classical models and experimental data.
Main Methods:
- Developed a discrete framework for a polydisperse cell model.
- Incorporated measured pore size distributions into the model.
- Derived a new equation from first principles connecting cell and medium efficiencies.
- Validated the model using ceramic filter data.
Main Results:
- The discrete model achieved a 5.4% root-mean-squared difference in filtration efficiency prediction for ceramic filters.
- The classical cell model showed a 26.4% root-mean-squared difference.
- The discrete model accurately predicted filtration of sub-100 nm particles, eliminating classical model bias.
- The model demonstrated generic prediction capability across different filtration scenarios.
Conclusions:
- The discrete polydisperse cell model offers a significant improvement over classical models for filtration performance prediction.
- This model accurately captures the impact of pore size distribution on filtration efficiency.
- The developed framework is essential for precise filter design and performance analysis, especially for fine particles.
Related Concept Videos
Filtration
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models
Typical Model Studies
Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model
Mechanistic Models: Compartment Models in Individual and Population Analysis
Theories of Dissolution: Diffusion Layer Model
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...

