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Updated: Dec 12, 2025

Preparation and Characterization of C60/Graphene Hybrid Nanostructures
Published on: May 15, 2018
Total Syntheses of C60- and C100-Dolichols
Kohtaro Hirao1, Risako Ono1, Yoshiyuki Manabe1,2
1Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan.
Abstract:
C60- and C100-dolichols were synthesized. A Z-selective Wittig reaction was achieved with high selectivity in a microflow system to realize the scalable supply of the Z-isoprene unit. An isoprene chain was efficiently elongated by an SN2-type coupling between allyl sulfone and allyl chloride using t-BuOK. These key reactions enabled the efficient syntheses of dolichols. This study will pave the way for the functional studies of dolichols.
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