Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Photochemical Electrocyclic Reactions: Stereochemistry01:26

Photochemical Electrocyclic Reactions: Stereochemistry

2.1K
The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
Selection Rules: Photochemical Activation
2.1K
Photoelectric Effect02:26

Photoelectric Effect

38.0K
When light of a particular wavelength strikes a metal surface, electrons are emitted. This is called the photoelectric effect. The minimum frequency of light that can cause such emission of electrons is called the threshold frequency, which is specific to the metal. Light with a frequency lower than the threshold frequency, even if it is of high intensity, cannot initiate the emission of electrons. However, when the frequency is higher than the threshold value, the number of electrons ejected...
38.0K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

8.3K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.3K
Cycloaddition Reactions: MO Requirements for Photochemical Activation01:12

Cycloaddition Reactions: MO Requirements for Photochemical Activation

2.5K
Some cycloaddition reactions are activated by heat, while others are initiated by light. For example, a [2 + 2] cycloaddition between two ethylene molecules occurs only in the presence of light. It is photochemically allowed but thermally forbidden.
2.5K
Photoluminescence: Applications01:14

Photoluminescence: Applications

895
Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...
895
Photoreceptors and Plant Responses to Light02:00

Photoreceptors and Plant Responses to Light

28.0K
Light plays a significant role in regulating the growth and development of plants. In addition to providing energy for photosynthesis, light provides other important cues to regulate a range of developmental and physiological responses in plants.
28.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scalable Correlated Local Approaches for Computing Valence and Core-Level Ionization Energies in Large Molecules.

Journal of chemical theory and computation·2026
Same author

Phenocopies of 22q11.2DS: revealing genetic diversity in clinically suspected 22q11.2 deletion syndrome.

Molecular and cellular pediatrics·2026
Same author

Development of Local Natural Orbital Arbitrary Order Coupled Cluster Methods and Assessment through Connected Quadruples.

The journal of physical chemistry. A·2026
Same author

Optimized Xanthenium Photocages with Fused Ring Systems for Photoactivated Chemotherapy and G Protein-Coupled Receptor Photopharmacology.

Journal of the American Chemical Society·2026
Same author

Accurate Core-Level Ionization Energies from an Affordable Second-Order Approach.

Journal of chemical theory and computation·2026
Same author

A Linear-Scaling Integral-Direct Explicitly Correlated Second-Order Møller-Plesset Approach.

Journal of chemical theory and computation·2026
Same journal

Proton-Gated Torsional Spring for Molecular Energy Storage.

Journal of the American Chemical Society·2026
Same journal

Topologically Programmed Dual-Channel Covalent Organic Frameworks Decouple Gas and Ion Fluxes for Acidic CO<sub>2</sub> Electroreduction.

Journal of the American Chemical Society·2026
Same journal

Plasmonic Re-Excitation Enables Superoxide-Mediated Ethane Conversion to Acetic Acid under Visible Light.

Journal of the American Chemical Society·2026
Same journal

Photocatalytic Controlled Halodefluorination of Perfluoroalkyl Compounds Using <i>N</i>-Arylphenothiazines.

Journal of the American Chemical Society·2026
Same journal

Photoinduced Disproportionation Enables Oxidative Addition of Aryl Iodides at a Gallium(I) Center.

Journal of the American Chemical Society·2026
Same journal

Biocatalytic C3 β-<i>O</i>-Glycosylation of Triterpenes and Sterols to Synthesize Natural and Unnatural Saponins.

Journal of the American Chemical Society·2026
See all related articles

Related Experiment Video

Updated: Dec 12, 2025

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
09:44

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

Published on: October 15, 2019

12.8K

Conditionally Activatable Visible-Light Photocages.

Márton Bojtár1, Krisztina Németh1, Farkas Domahidy1

  • 1"Lendület" Chemical Biology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences. Magyar tudósok krt. 2, H-1117 Budapest, Hungary.

Journal of the American Chemical Society
|August 14, 2020
PubMed
Summary
This summary is machine-generated.

This study introduces a new photocage that can be activated by bioorthogonal chemistry, enabling controlled light-induced cargo release. This "click-armed" photocage shows efficient release and live-cell applicability for drug delivery and imaging.

More Related Videos

Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist
07:48

Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist

Published on: April 25, 2018

6.5K
An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
11:20

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

Published on: August 30, 2017

7.7K

Related Experiment Videos

Last Updated: Dec 12, 2025

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
09:44

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

Published on: October 15, 2019

12.8K
Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist
07:48

Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist

Published on: April 25, 2018

6.5K
An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
11:20

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

Published on: August 30, 2017

7.7K

Area of Science:

  • Organic Chemistry
  • Chemical Biology
  • Photochemistry

Background:

  • Photocages are crucial tools for controlled release of molecules.
  • Existing photocages often lack conditional activation or require specific wavelengths.
  • Developing photocages with tunable photoresponsivity is essential for advanced applications.

Purpose of the Study:

  • To demonstrate a proof of concept for conditionally activatable photocages.
  • To develop a novel vinyltetrazine-derivatized coumarin-based photocage.
  • To enable light-induced cargo release through bioorthogonal chemistry.

Main Methods:

  • Synthesis of a vinyltetrazine-derivatized coumarin photocage.
  • Bioorthogonal transformation of the tetrazine moiety.
  • Photochemical release studies using blue light.
  • Live-cell imaging experiments with a fluorogenic probe.

Main Results:

  • The tetrazine form of the photocage showed disabled photoactivity.
  • Bioorthogonal transformation restored full photoresponsivity.
  • Irradiation with blue light resulted in fast and efficient cargo release.
  • Conditional release of a fluorogenic probe in live cells was achieved via mitochondrial pretargeting.

Conclusions:

  • Conditionally activatable photocages can be designed using bioorthogonal chemistry.
  • The developed photocage offers tunable photoresponsivity for controlled cargo release.
  • This technology has potential applications in targeted drug delivery and biological imaging.