Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

7.6K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
7.6K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

6.3K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.3K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

8.3K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
8.3K
Autophagic Cell Death01:18

Autophagic Cell Death

4.1K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Carbon Nanostructure-Initiator Mass Spectrometry for Metabolic Biomarker Detection of Prediabetes.

Analytical chemistry·2026
Same author

Therapeutic applications and prospects of inhalable mesoporous silica nanoparticles in pulmonary diseases.

Nanoscale·2026
Same author

Coordination orientation isomerism boosting concerted hydrogen peroxide photosynthesis.

Nature communications·2026
Same author

Hollow micro-/nanostructures for enhanced pathogen theranostics.

Chemical Society reviews·2026
Same author

Nanoporous Materials in Biomedical Research: Progress and Potential.

International journal of nanomedicine·2026
Same author

Interfacial Chemistry-Tailored Silica&Metal-Based Heterostructures: from Rational Design to Antibacterial Applications.

Small (Weinheim an der Bergstrasse, Germany)·2026

Related Experiment Video

Updated: Dec 12, 2025

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

9.0K

Eliciting Immunogenic Cell Death via a Unitized Nanoinducer.

Zan Dai1, Jie Tang1, Zhengying Gu1

  • 1Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Brisbane, QLD 4072, Australia.

Nano Letters
|August 14, 2020
PubMed
Summary

A novel nanoinducer combines organosilica nanoparticles, curcumin, and iron oxide to effectively induce cancer cell death and stimulate anti-tumor immunity. This approach offers improved potency and specificity over traditional chemotherapy for cancer immunotherapy.

Keywords:
endoplasmic reticulum stressimmunogenic cell deathnanoinduceroxidative stress

More Related Videos

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
08:02

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells

Published on: September 23, 2021

2.9K
Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
10:13

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

9.4K

Related Experiment Videos

Last Updated: Dec 12, 2025

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

9.0K
In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
08:02

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells

Published on: September 23, 2021

2.9K
Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
10:13

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

9.4K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Research

Background:

  • Chemotherapeutics can induce immunogenic cell death (ICD) to sensitize tumors and promote anticancer immunity.
  • Traditional ICD inducers often lack tumor selectivity and cause severe side effects, limiting their clinical application.

Purpose of the Study:

  • To develop a unitized nanoinducer for potent and cancer-cell-specific induction of ICD.
  • To enhance cancer immunotherapy by overcoming the limitations of conventional ICD agents.

Main Methods:

  • Fabrication of a nanoinducer using disulfide-bond-incorporated organosilica nanoparticles, curcumin (CUR), and iron oxide nanoparticles.
  • Evaluation of the nanoinducer's ability to deplete glutathione, produce hydroxyl radicals, and inhibit thioredoxin reductase.
  • Assessment of intracellular oxidative stress, endoplasmic reticulum stress, ICD induction, and systemic antitumor immunity.

Main Results:

  • The combined nanoinducer components demonstrated synergistic activity in inducing ICD, unlike individual components.
  • The nanoinducer effectively depleted glutathione, produced hydroxyl radicals, and inhibited thioredoxin reductase, leading to increased oxidative and endoplasmic reticulum stress.
  • Significant ICD induction and systemic antitumor immunity were observed.

Conclusions:

  • The unitized nanoinducer exhibits superior ICD-inducing activity and cancer cell selectivity compared to doxorubicin.
  • This novel nanoinducer represents a promising strategy for effective cancer immunotherapy with reduced side effects.