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Hyperthyroidism as a Precipitant Factor for Cerebral Venous Thrombosis: A Case Report

Ahmed Elkhalifa Elawad Elhassan1, Mohammed Omer Khalil Ali2, Amina Bougaila2

  • 1University of Khartoum, Khartoum, Sudan.

Journal of Investigative Medicine High Impact Case Reports
|August 14, 2020
PubMed

Insights

Hyperthyroidism can precipitate cerebral venous sinus thrombosis (CVT), a rare but serious condition. This case report details a patient with uncontrolled hyperthyroidism who developed superior sagittal sinus thrombosis and recovered with anticoagulation.

Area of Science:

  • Neurology
  • Endocrinology
  • Vascular Medicine

Background:

  • Cerebral venous sinus thrombosis (CVT) is a rare cerebrovascular disorder with various known causes.
  • The association between hyperthyroidism and CVT is not well-established.
  • Hyperthyroidism is a condition characterized by excessive thyroid hormone production, potentially affecting coagulation.

Observation:

  • A 41-year-old male with a four-year history of hyperthyroidism presented with seizures.
  • Computed tomography and MR venography confirmed superior sagittal sinus thrombosis.
  • Laboratory results indicated uncontrolled hyperthyroidism, with no other underlying cause identified.

Findings:

  • The patient's hyperthyroidism was identified as the likely procoagulant factor leading to superior sagittal sinus thrombosis.
  • Anticoagulation therapy resulted in rapid clinical improvement.
  • Follow-up imaging demonstrated complete recanalization of the superior sagittal sinus within two months.

Implications:

  • This case highlights hyperthyroidism as a potential, albeit uncommon, precipitant of CVT.
  • Recognizing hyperthyroidism in patients with CVT may be crucial for effective management.
  • Further research is warranted to elucidate the prothrombotic mechanisms linking hyperthyroidism and CVT.

Keywords:
CVTcerebral venous sinus thrombosishypercoagulable statehyperthyroidismsuperior sagittal sinus thrombosis

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