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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
338
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

119
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Methods for Studying Drug Absorption: In vitro01:16

Methods for Studying Drug Absorption: In vitro

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In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
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Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices
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Engineered Site-specific Vesicular Systems for Colonic Delivery: Trends and Implications.

Honey Goel1, Karan Razdan2, Richu Singla3

  • 1University Institute of Pharmaceutical Sciences and Research, Baba Farid University of Health Sciences, Faridkot, India.

Current Pharmaceutical Design
|August 14, 2020
PubMed
Summary

Colon-specific coated liposomal systems (CSLS) offer targeted oral delivery, overcoming challenges like drug degradation and improving bioavailability. Despite advancements, no CSLS has reached the market, though industrial viability remains promising.

Keywords:
Coated liposomesactive targetingcolon drug deliverycolon specific liposomal systems (CSLS)immunoliposomesnanoliposomesphytochemicals

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Tissue Engineering of the Intestine in a Murine Model
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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Oral drug delivery to the colon faces challenges including drug degradation in the upper gastrointestinal tract and enzymatic instability.
  • Colon-specific coated liposomal systems (CSLS) present a promising strategy for targeted colonic delivery, enhancing drug stability and bioavailability.
  • Existing liposomal formulations for oral delivery encounter barriers like gastrointestinal instability and membrane permeability issues.

Purpose of the Study:

  • To review the engineering processes involved in developing industrially viable CSLS for targeted colonic drug delivery.
  • To explore advancements in CSLS that improve stability and permeability for oral administration.
  • To address the challenges hindering the clinical translation of oral CSLS.

Main Methods:

  • Review of current literature on CSLS formulations and their modifications.
  • Analysis of strategies for enhancing liposome stability and permeability for oral delivery.
  • Evaluation of factors influencing the industrial viability and scale-up of CSLS.

Main Results:

  • Modifications to lipid bilayer composition, polymers, and ligands have improved CSLS stability and permeability for oral delivery.
  • Despite technological advancements, no oral CSLS has achieved commercialization for targeted colon delivery.
  • CSLS demonstrate significant potential for industrial manufacturing due to their simple, low-cost design.

Conclusions:

  • CSLS hold considerable promise for targeted colonic drug delivery, offering protection from degradation and prolonged residence time.
  • Further research and development are needed to overcome barriers to clinical translation and commercialization of oral CSLS.
  • The industrial viability and cost-effectiveness of CSLS make them an attractive area for pharmaceutical manufacturers.