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Thiol/Disulfide Homeostasis in Patients With Erectile Dysfunction
Uygar Micoogullari1, Omer Faruk Karatas2, Erdem Kisa1
1Department of Urology, Tepecik Education and Research Hospital, University of Health Sciences, İzmir, Turkey.
The Journal of Sexual Medicine
|August 14, 2020
Summary
Oxidative stress, indicated by altered thiol/disulfide homeostasis, is linked to erectile dysfunction (ED). This imbalance may contribute to ED
Area of Science:
- Biochemistry
- Urology
- Oxidative Stress Research
Background:
- Oxidative stress and its imbalance with antioxidant defenses are implicated in erectile dysfunction (ED) pathogenesis.
- Limited data exists on the direct association between oxidative stress and ED.
Purpose of the Study:
- To determine and compare oxidant and antioxidant status in ED patients versus healthy controls.
- To utilize a novel automated assay for thiol/disulfide homeostasis testing.
Main Methods:
- Included 123 ED patients and 90 healthy controls.
- Assessed ED using the International Index of Erectile Function questionnaire.
- Employed a novel thiol/disulfide homeostasis test to measure serum antioxidant (total thiol [toSH], native thiol [SH]) and oxidant (disulfide [SS]) levels.
Main Results:
- Significant differences in toSH, SH, SS/toSH%, and SS/SH% ratios were observed between ED and control groups.
- Disulfide (SS) parameters were elevated in ED patients.
- A correlation was found between ED severity and thiol/disulfide parameters: increased SS and decreased toSH/SH with greater ED severity.
Conclusions:
- Thiol/disulfide homeostasis is altered in ED, suggesting a role in its pathophysiology.
- The findings may contribute to early diagnosis and treatment strategies for ED.
- Novel automated assays offer reliable assessment of oxidative/antioxidative balance.
Keywords:
Antioxidant TreatmentsErectile DysfunctionOxidative StressReactive Oxygen SpeciesThiol/Disulfide HomeostasisMore Related Videos
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