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Updated: Dec 12, 2025
Thermal Ablation for the Treatment of Abdominal Tumors
Published on: March 7, 2011
Cryoablation: A promising non-operative therapy for low-risk breast cancer
Zaina Habrawi1, Michael W Melkus1, Sonia Khan1
1Department of Surgery, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, 79430, USA.
Background:
The aim of this study was to evaluate the feasibility of cryoablation for early-stage low-risk breast cancer without tumor resection.
Methods:
Women diagnosed with ER+, PR+, and HER2-infiltrating ductal carcinomas ≤1.5 cm were treated with cryoablation. The non-surgical procedure used a Visica® 2 Treatment System with ultrasound guidance for ablation of the tumor with a 1 cm margin. Patients were monitored at 6-month intervals by MRI, mammogram, and ultrasound.
Results:
Twelve patients with unifocal breast cancer were treated with cryoablation for local control without follow-up tumor resection. All patients received adjuvant endocrine therapy, and none had radiation. The median follow-up was 28.5 (range = 4-41) months with 11 patients having at least one six-month follow-up. All imaging modalities showed complete ablation of target zone 11/11 (100%). Four patients (33.3%) have been followed up for ≥ 2 years with no local failure or residual disease.
Conclusion:
Cryoablation of early-stage low-risk (ER+, PR+, and HER2-) breast cancer is a safe alternative to surgery.
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