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Related Experiment Video

Updated: Dec 12, 2025

Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice

Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice

Published on: July 20, 2022

Visualizing Nudivirus Assembly and Egress.

Sailakshmi Velamoor¹, Allan Mitchell², Bruno M Humbel³

¹Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.

|August 14, 2020

Summary

This summary is machine-generated.

Nudiviruses remodel the nuclear envelope for assembly and transport. This study reveals unique mechanisms of nuclear membrane reconfiguration during nudivirus infection.

Keywords:

electron microscopy enveloped viruses nudiviruses viral assembly

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Last Updated: Dec 12, 2025

Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice

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Published on: July 20, 2022

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Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus

Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus

Published on: July 27, 2021

Area of Science:

Virology
Cell Biology
Structural Biology

Background:

Enveloped viruses utilize host cell membranes for virion assembly.
Viruses replicating within the nucleus employ specialized strategies to manipulate the nuclear environment.
Understanding nuclear membrane dynamics is crucial for comprehending viral replication and cellular processes.

Purpose of the Study:

To investigate the cellular changes and viral assembly mechanisms during nudivirus infection using electron microscopy.
To characterize the unique process of virion transport across the nuclear membrane.
To elucidate the structural basis of nuclear morphological reconfigurations induced by nudiviruses.

Main Methods:

High-resolution electron microscopy was employed to visualize cellular alterations.
Three-dimensional reconstructions were generated to analyze the nuclear membrane remodeling.
Infection dynamics of Oryctes rhinoceros nudivirus were studied at the ultrastructural level.

Main Results:

Nudivirus infection triggers significant remodeling of the nuclear membrane.
A unique mechanism for the assembly, packaging, and transport of virions through the nuclear envelope was identified.
Vesicle-associated virions are released into the cytoplasm via nuclear membrane modifications.
Oryctes rhinoceros nudivirus infection induces dramatic intranuclear membrane remodeling.

Conclusions:

Nuclear morphological reconfigurations are a key feature of nudiviral infection.
A novel model for nudivirus assembly, involving nuclear packaging within fully enveloped virions, is proposed.
These findings provide critical insights into the interaction between viruses and the nuclear envelope.