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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

623
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
623
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

645
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
645

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Stimulus-Responsive Sequential Release Systems for Drug and Gene Delivery.

Sepideh Ahmadi1,2, Navid Rabiee3, Mojtaba Bagherzadeh3

  • 1Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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Summary

Researchers are developing advanced delivery systems for sequential drug and gene release. These systems offer targeted therapies for cancer and other diseases, improving treatment efficacy and reducing side effects.

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cancer nanomedicinesequential drug and gene releasestimulus-responsive nanoparticlessynergistic combinationstemporal control

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Developing advanced drug delivery systems is crucial for treating complex diseases like cancer.
  • Controlled and sequential release of therapeutics offers enhanced efficacy and reduced side effects.

Purpose of the Study:

  • To review recent advancements in sequential release (SR)-based delivery systems.
  • To highlight the application of these systems in cancer and other diseases.

Main Methods:

  • Review of studies on micro- and nanocarrier-based delivery systems.
  • Analysis of stimuli-responsive mechanisms for sequential release (pH, redox, light, etc.).

Main Results:

  • SR systems can release multiple drugs or genes in programmed temporal or spatial sequences.
  • These systems respond to various internal and external stimuli.
  • Potential for synergistic effects of combined gene and drug delivery.

Conclusions:

  • SR delivery systems show significant promise for targeted cancer therapy.
  • These advanced systems can improve therapeutic outcomes and minimize adverse effects.