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Updated: Dec 12, 2025
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
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COVID-19 infection recurrence presenting with meningoencephalitis
M Mardani1, S Alireza Nadji2, K Aghazadeh Sarhangipor3
1Infectious Disease and Tropical Medicine Research Center, Iran.
New Microbes and New Infections
|August 14, 2020
Summary
A COVID-19 relapse case highlights neurological symptoms, including meningoencephalitis, appearing during convalescence. This underscores the need for regular patient monitoring post-infection to detect potential relapses.
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- Coronavirus disease 2019 (COVID-19) can affect multiple organ systems, including the central nervous system.
- Neurological manifestations can be initial symptoms or occur during relapse of COVID-19.
Purpose of the Study:
- To report a case of COVID-19 relapse with acute meningoencephalitis.
- To emphasize the importance of monitoring patients for neurological symptoms during convalescence.
Main Methods:
- Case report of a 64-year-old woman with confirmed COVID-19.
- Utilized nasopharyngeal swab, cerebrospinal fluid, and tracheal aspiration for RT-PCR testing.
- Monitored COVID-19 serum antibodies.
Main Results:
- Initial COVID-19 infection led to respiratory distress with negative RT-PCR post-treatment.
- Relapse occurred weeks later, presenting as acute meningoencephalitis.
- RT-PCR tests from cerebrospinal fluid and respiratory specimens turned positive again; serum antibodies remained negative.
Conclusions:
- Neurological symptoms, such as meningoencephalitis, can manifest as an initial presentation or during relapse of COVID-19.
- Regular patient evaluation during convalescence is crucial for detecting relapses and neurological involvement.
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