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Gene probe analysis demonstrates independent clonal evolution of co-existent chronic myeloid and chronic lymphocytic
P J Browett1, J Pattinson, J Pinkney
1Department of Haematology, Royal Free Hospital, Hampstead, London, U.K.
European Journal of Haematology
|February 1, 1988
Abstract:
We describe a case of Philadelphia-positive chronic myeloid leukaemia occurring simultaneously with B-cell chronic lymphocytic leukaemia in a 69-yr-old male. Gene probe analysis of DNA from both peripheral blood and bone marrow provided evidence for the independent evolution of 2 clones in this case, with a predominant population showing immunoglobulin heavy chain gene rearrangement and a smaller population showing a rearrangement within the breakpoint cluster region of chromosome 22.