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This study reports two postmortem cases involving mebroqualone, a methaqualone analogue. Blood concentrations varied significantly, highlighting the need for more research on this designer drug's toxicity.

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Area of Science:

  • Forensic Toxicology
  • Pharmacology
  • Drug Analysis

Background:

  • Mebroqualone is an analogue of methaqualone.
  • Limited data exists on the toxicity of mebroqualone.
  • Designer drugs pose challenges in forensic toxicology.

Purpose of the Study:

  • To report and compare two postmortem blood concentrations of mebroqualone.
  • To contribute to the understanding of mebroqualone toxicity.
  • To document analytical findings for mebroqualone in forensic cases.

Main Methods:

  • Liquid-liquid extraction of mebroqualone from postmortem blood.
  • Gas chromatography-mass spectrometry (GC-MS) for drug analysis.
  • Case study methodology comparing two distinct scenarios.

Main Results:

  • Case 1: Accidental death (house fire) with blood mebroqualone concentration of 10,228 ng/mL.
  • Case 2: Suicide by train with blood mebroqualone concentration of 115 ng/mL.
  • First report comparing two postmortem mebroqualone blood concentrations in scientific literature.

Conclusions:

  • Mebroqualone was detected in postmortem blood samples.
  • Significant variation in blood concentrations was observed between cases.
  • Further research is warranted to establish toxicological reference ranges for mebroqualone.