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Updated: Dec 12, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.8K

Rate-dependent aberrancy and cardiac resynchronization therapy

Sohaib Haseeb1, Enes Elvin Gul2

  • 1College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia.

Pacing and Clinical Electrophysiology : PACE
|August 14, 2020
PubMed

Insights

Left bundle branch block (LBBB) causes heart dyssynchrony and remodeling. Cardiac resynchronization therapy (CRT) improved symptoms in a patient with rate-dependent LBBB and systolic dysfunction.

Area of Science:

  • Cardiology
  • Electrophysiology

Background:

  • Left bundle branch block (LBBB) can cause left ventricular (LV) dyssynchrony and remodeling.
  • LBBB may be rate-dependent and associated with LV systolic dysfunction.

Observation:

  • A 57-year-old man presented with exertional dyspnea.
  • He had rate-dependent LBBB and impaired LV systolic function.

Findings:

  • Cardiac resynchronization therapy (CRT) is effective for LBBB patients.
  • CRT improved hemodynamics and clinical symptoms in the described case.

Implications:

  • CRT is a viable treatment for patients with LBBB, dyssynchrony, and systolic dysfunction.
  • This case highlights CRT's benefit in managing complex cardiac conditions.

Keywords:
cardiac resynchronization therapydyssynchronyleft bundle branch block

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