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Branching morphogenesis as a driver of renal development
1Department of Anatomy and Developmental Biology, Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.
Anatomical Record (Hoboken, N.J. : 2007)
|August 14, 2020
Summary
Branching morphogenesis is key for organ development, forming essential tubule networks like the kidney's collecting system. This review explores ureteric bud patterning and its shared mechanisms across organs.
Area of Science:
- Developmental Biology
- Organogenesis
- Cell Signaling
Background:
- Branching morphogenesis is crucial for forming organs like the kidney, lung, and pancreas.
- Epithelial tubule networks are vital for secretion, excretion, and exchange.
- Kidney development involves the ureteric bud forming the collecting duct system.
Purpose of the Study:
- To review advances in understanding ureteric bud patterning in kidney development.
- To explore shared mechanisms of branching morphogenesis across different organs.
Main Methods:
- Review of recent scientific literature on branching morphogenesis.
- Analysis of cell signaling interactions between epithelial and mesenchymal cells.
Main Results:
- Branching morphogenesis typically involves bud-like anlage elaboration via bifurcation.
- Interactions between epithelial progenitor cells and mesenchymal cells guide branching.
- Kidney development features a dynamic signaling relationship between ureteric bud tips and nephron progenitors.
Conclusions:
- Understanding ureteric bud patterning offers insights into broader organogenesis.
- Shared mechanisms of branching morphogenesis exist across various organs.
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