Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Postnatal decrease in insulin binding to erythrocytes in infants of diabetic mothers.

P Lautala1, R Puukka, M Knip

  • 1Department of Pediatrics, University of Oulu, Finland.

The Journal of Clinical Endocrinology and Metabolism
|April 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of Enterovirus Antibodies during Early Childhood Using a Multiplex Immunoassay.

Microbiology spectrum·2023
Same author

Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1.

Nature communications·2021
Same author

Circulating β cell-specific CD8<sup>+</sup> T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes.

Clinical and experimental immunology·2019
Same author

Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk.

Pediatric diabetes·2017
Same author

Serum carotenoid and tocopherol concentrations and risk of asthma in childhood: a nested case-control study.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2017
Same author

The association of the HLA-A*24:02, B*39:01 and B*39:06 alleles with type 1 diabetes is restricted to specific HLA-DR/DQ haplotypes in Finns.

HLA·2017

Infants of mothers with diabetes mellitus (IDM) show similar insulin receptor binding at birth but a greater postnatal decrease in binding. This impacts insulin action, contributing to macrosomia and hypoglycemia risk in IDM infants.

Area of Science:

  • Endocrinology
  • Neonatal Medicine
  • Metabolic Disorders

Background:

  • Infants of mothers with diabetes mellitus (IDM) often experience macrosomia and hypoglycemia.
  • The role of insulin receptors in these conditions requires clarification.

Purpose of the Study:

  • To investigate insulin receptor binding in erythrocytes of infants of mothers with insulin-treated diabetes mellitus (IDM).
  • To correlate insulin binding with macrosomia and hypoglycemia in IDM infants.

Main Methods:

  • Studied insulin binding in erythrocytes from umbilical and peripheral venous blood of IDM and normal infants.
  • Matched infants for gestational and postnatal age.
  • Measured plasma free insulin concentrations and assessed hypoglycemia incidence.

Related Experiment Videos

Main Results:

  • IDM infants exhibited macrosomia and higher plasma insulin levels.
  • Erythrocyte insulin binding was similar at birth but decreased significantly more in IDM infants postnatally.
  • Postnatal decrease in binding was due to reduced receptor affinity and concentration in IDM infants.

Conclusions:

  • Similar initial insulin receptor binding in IDM infants despite hyperinsulinemia suggests altered insulin action contributing to macrosomia and hypoglycemia.
  • The marked postnatal decrease in insulin binding may explain the reduced hypoglycemia risk in IDM infants after the first few days.