Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.4K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.4K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

758
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
758
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

2.3K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
2.3K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.1K
Neural Regulation01:37

Neural Regulation

42.7K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
42.7K
The Blood-brain Barrier00:49

The Blood-brain Barrier

51.5K
Overview
51.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of the consistency between interns in accurate quantification of split kidney glomerular filtration rate.

Clinical radiology·2025
Same author

Predictive model for postoperative unrecovered olfactory function in CRSwNP patients with olfactory disorder.

Rhinology·2024
Same author

Body mass index’s effect on CRSwNP extends to pathological endotype and recurrence.

Rhinology·2024
Same author

[Clinical, pathological and genetic characteristics of 8 patients with distal hereditary motor neuropathy].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2021
Same author

Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution.

Science advances·2020
Same author

Activation of central galanin receptor 2 mitigated insulin resistance in adipocytes of diabetic rats.

Journal of endocrinological investigation·2020

Related Experiment Video

Updated: Dec 12, 2025

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
07:49

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

3.6K

The Microbiome as a Modifier of Neurodegenerative Disease Risk.

P Fang1, S A Kazmi1, K G Jameson1

  • 1Department of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Cell Host & Microbe
|August 14, 2020
PubMed
Summary

The gut microbiome influences neurodegenerative diseases (NDs). This review explores microbiome roles in aging and NDs, including Parkinson's and Alzheimer's, and potential microbiome-targeted interventions.

Keywords:
ALSAlzheimer'sParkinson'sagingmicrobiomeneurodegenerative disease

More Related Videos

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

3.3K
High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health
11:40

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

Published on: April 28, 2022

3.1K

Related Experiment Videos

Last Updated: Dec 12, 2025

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
07:49

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

3.6K
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

3.3K
High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health
11:40

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

Published on: April 28, 2022

3.1K

Area of Science:

  • Neuroscience
  • Microbiology
  • Immunology

Background:

  • The gut microbiome plays a crucial role in host health and disease.
  • Emerging evidence links gut dysbiosis to neurodegenerative diseases (NDs).
  • Understanding these connections is vital for developing novel therapeutic strategies.

Purpose of the Study:

  • To review the current understanding of the gut microbiome's role in aging and NDs.
  • To summarize findings from human and animal studies on microbiome alterations in NDs.
  • To explore potential mechanisms and therapeutic interventions targeting the microbiome.

Main Methods:

  • Comprehensive literature review of human and animal studies.
  • Analysis of microbiome alterations in Parkinson's, Alzheimer's, ALS, and Huntington's diseases.
  • Evaluation of immunological, neuronal, and metabolic pathways involved.

Main Results:

  • Significant alterations in gut microbiome composition are observed across various NDs.
  • Microbiome manipulation in animal models causally impacts disease phenotypes.
  • Immunological, neuronal, and metabolic mechanisms mediate the gut-brain axis in NDs.

Conclusions:

  • The gut microbiome is a significant factor in ND susceptibility and progression.
  • Cross-cutting microbial influences exist across multiple NDs.
  • Microbiome-targeted interventions hold promise for ND management.