Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.5K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.7K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.7K
Cancer Therapies02:49

Cancer Therapies

9.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

6.6K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
6.6K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

17.8K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
17.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reproductive toxicity of benzo[α]pyrene: Effects, mechanisms, and perspectives.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP·2026
Same author

The Genetically Homogeneous Population Structure of <i>Evynnis cardinalis</i> Along the Chinese Coast Revealed by Whole Genome Sequencing.

Evolutionary applications·2026
Same author

Glucose cotransporter-2 inhibitors on mortality and hospitalization in heart failure patients: a comprehensive meta-analysis.

Frontiers in endocrinology·2026
Same author

A PEGylated nanobody against HBsAg exhibits pleiotropic antiviral efficacy in hepatitis B models.

Journal of nanobiotechnology·2026
Same author

A Single-Center Clinical Analysis of 121 Pediatric Cases with Pulmonary Atresia and Ventricular Septal Defect Undergoing the Pulmonary Artery Flow Study.

World journal for pediatric & congenital heart surgery·2026
Same author

The Role of Stroke Severity in the Association between Hypoperfusion Intensity Ratio and Futile Reperfusion after Endovascular Treatment.

European neurology·2026

Related Experiment Video

Updated: Dec 12, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.0K

Hydroxamic acid hybrids as the potential anticancer agents: An Overview.

Wenhua Liu1, Yuchen Liang2, Xiaoyong Si3

  • 1Department of Psychology and Mental Health, Huaihe Hospital of Henan University, Kaifeng, 475000, Henan, PR China.

European Journal of Medicinal Chemistry
|August 14, 2020
PubMed
Summary

Hydroxamic acid hybrids show promise as anticancer agents by inhibiting histone deacetylase. Combining this scaffold with other drugs may overcome resistance and enhance cancer treatment efficacy.

Keywords:
AnticancerDrug resistanceHybrid compoundsHydroxamic acidMechanism of actionStructure-activity relationship

More Related Videos

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

12.6K
Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells
10:13

Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells

Published on: December 22, 2010

15.4K

Related Experiment Videos

Last Updated: Dec 12, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.0K
Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

12.6K
Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells
10:13

Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells

Published on: December 22, 2010

15.4K

Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Oncology

Background:

  • Hydroxamic acid derivatives are established histone deacetylase (HDAC) inhibitors.
  • Several HDAC inhibitors based on hydroxamic acids are clinically approved anticancer drugs.
  • Hydroxamic acid derivatives serve as valuable scaffolds for novel anticancer agent development.

Purpose of the Study:

  • To review recent advancements in hydroxamic acid hybrids for cancer therapy.
  • To focus on anticancer activity, structure-activity relationships (SAR), and mechanisms of action.
  • To highlight the potential of rational design in developing targeted cancer treatments.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of structure-activity relationships in hydroxamic acid hybrids.
  • Examination of documented anticancer mechanisms of action.

Main Results:

  • Hydroxamic acid hybrids demonstrate significant anticancer potential.
  • Hybridization strategies can enhance specificity and overcome drug resistance.
  • Structure-activity relationship studies guide the rational design of potent analogs.

Conclusions:

  • Hydroxamic acid hybrids represent a promising class of anticancer agents.
  • Rational design and hybridization are key to improving therapeutic outcomes.
  • Further research into these compounds may lead to novel cancer interventions.