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Related Experiment Video

Updated: Dec 12, 2025

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
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G-quadruplex based biosensor: A potential tool for SARS-CoV-2 detection.

Hui Xi1, Mario Juhas2, Yang Zhang1

  • 1College of Science, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong, 518055, China.

Biosensors & Bioelectronics
|August 14, 2020
PubMed
Summary

G-quadruplex structures offer enhanced biosensor capabilities for detecting various targets, including SARS-CoV-2. These guanine-rich DNA or RNA formations show improved affinity and specificity in novel electrochemical and optical biosensing applications.

Keywords:
BiosensorElectrochemical biosensorG-quadruplexOptical biosensorSARS-CoV-2Virus detection

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Area of Science:

  • Biochemistry and Molecular Biology
  • Nanotechnology and Biosensing

Background:

  • G-quadruplexes are non-canonical nucleic acid structures formed by guanine-rich sequences.
  • Their conformation and function depend on strand number, cation type, and binding targets.
  • Recent discoveries highlight G-quadruplexes' potential in novel biosensors due to unique folding and ligand-binding properties.

Purpose of the Study:

  • To review the latest advancements in G-quadruplex based biosensors.
  • To focus on G-quadruplex sequences and their recent applications.
  • To explore the potential of G-quadruplex biosensors for detecting SARS-CoV-2.

Main Methods:

  • Review of recent scientific literature on G-quadruplex structures and biosensor development.
  • Analysis of G-quadruplex sequences and their role in biosensing.
  • Evaluation of G-quadruplex based electrochemical and optical biosensors.

Main Results:

  • G-quadruplex based biosensors exhibit improved affinity and specificity compared to traditional sensors.
  • These biosensors can detect diverse analytes including metal ions, proteins, and nucleic acids.
  • Novel G-quadruplex biosensors demonstrate enhanced performance for pathogen detection, including SARS-CoV-2.

Conclusions:

  • G-quadruplex based biosensors represent a promising frontier in diagnostics.
  • Their unique properties offer advantages for sensitive and specific detection of various targets.
  • Further development holds significant potential for infectious disease surveillance, particularly for SARS-CoV-2.