Construction of induced pluripotent stem cell line (ZZUi0017-A) from the fibroblast cells of a female patient with
Jing Yang1, Han Liu1, Huifang Sun1
1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Zhengzhou University, Zhengzhou, Henan 450001, China.
Abstract:
Ataxia is a common clinical symptom of neurodegenerative diseases, such as spinocerebellar ataxia, Parkinson's disease. Spinocerebellar ataxia includes more than 40 types. In clinical work, we collected the clinical data and skin tissue of one patient with SCA6 who have definitive genetic test results. More than that, we reprogrammed the patient derived fibroblast cells to induced pluripotent stem cells (iPSCs) to construct a SCA6 pathological cell model. The cell line was proved having good pluripotency through detection of pluripotent marker and teratoma formation. This iPS cell line is a special cell model for revealing mechanism and identifying potential therapeutic targets.
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