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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Chronic Kidney Disease III: Interprofessional Care01:28

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease I: Introduction01:25

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease IV: Nursing Management01:18

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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[What's new in CKD-MBD?]

Vincent Brandenburg1

  • 1Klinik für Kardiologie und Nephrologie, Rhein-Maas-Klinikum GmbH.

Deutsche Medizinische Wochenschrift (1946)
|August 14, 2020
PubMed
Summary

This review summarizes recent advances in chronic kidney disease-mineral and bone disorder (CKD-MBD), focusing on phosphate, vitamin D, and SGLT2 inhibitors. It highlights the need for more high-quality trials to improve CKD-MBD treatment.

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiovascular Medicine

Background:

  • Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a complex syndrome affecting patients with chronic kidney disease.
  • CKD-MBD encompasses renal osteodystrophy, mineral imbalances, and cardiovascular complications.

Purpose of the Study:

  • To provide an updated summary of clinically significant developments in CKD-MBD.
  • To assess the evidence base for novel aspects and innovative treatments in CKD-MBD.

Main Methods:

  • Literature review and synthesis of recent clinical findings.
  • Focus on key areas including phosphate management, secondary hyperparathyroidism, vitamin D, arteriosclerosis, renal bone disease, and SGLT2 inhibitors.

Main Results:

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  • Recent developments cover phosphate control, vitamin D therapy, and the role of SGLT2 inhibitors in CKD-MBD.
  • The evidence supporting novel CKD-MBD interventions varies in quality.

Conclusions:

  • Nephrologists require more robust, large-scale randomized controlled trials to optimize CKD-MBD therapies.
  • Evidence-based strategies are crucial for managing mineral and bone disorders in chronic kidney disease.