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Estimation of extracellular fluid volume from plasma clearance on technetium-99m DTPA by a single-injection,
C D Russell1, P G Bischoff, K L Rowell
1Division of Nuclear Medicine, University of Alabama Hospital, Birmingham 35233.
Abstract:
A simple method is presented for estimating extracellular fluid volume from the plasma clearance of [99mTc])DTPA or [169Yb]DTPA. Two plasma samples are required, at 1 and 3 hr, following a single intravenous injection. (The same plasma samples can be used for measurement of glomerular filtration rate.) Using the complete plasma clearance curve as a reference (eight samples at 10 to 240 min), the error of the two-sample method in 40 patients was 1.5 I for [99mTc]DTPA, 2.1 I for [169Yb]DTPA (residual standard deviation).