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A new tremulane sesquiterpene from Irpex lacteus by solid-state fermentation
Cheng-Tong Sun1, Jia-Peng Wang1, Yan Shu1
1School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China.
Natural Product Research
|August 15, 2020
Summary
Researchers discovered a new compound, lactedine, and seven known compounds from the fungus Irpex lacteus. Structural analysis confirmed the identity of these novel and known tremulane sesquiterpenes.
Area of Science:
- Natural Product Chemistry
- Mycology
- Organic Chemistry
Background:
- The fungus Irpex lacteus is a source of bioactive natural products.
- Sesquiterpenes and triterpenes are classes of organic compounds with diverse biological activities.
Purpose of the Study:
- To isolate and characterize chemical constituents from the fungus Irpex lacteus.
- To identify novel and known compounds, particularly tremulane sesquiterpenes.
Main Methods:
- Extraction and isolation of compounds from fungal cultures.
- Structure elucidation using extensive spectroscopic data (NMR, MS).
- Application of DP4+ probability analyses for structural confirmation.
Main Results:
- Isolation of a new tremulane sesquiterpene, named lactedine (1).
- Identification of seven known tremulane sesquiterpenes (2-8).
- Characterization of one known triterpene (9).
Conclusions:
- The chemical investigation of Irpex lacteus yielded a new sesquiterpene and several known related compounds.
- The structures of the isolated compounds were rigorously determined using advanced spectroscopic techniques and computational analysis.
