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Updated: Dec 12, 2025
Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
Published on: July 30, 2016
Melatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP rats
Oğuzhan Doğanlar1, Zeynep Banu Doğanlar1, Mehmet Akif Ovali2
1Department of Medical Biology, Faculty of Medicine, Trakya University , Edirne, Turkey.
Objective:
This study aimed to investigate the effects of melatonin on cardiac oxidative stress and apoptosis in the fetal heart in RUPP rats.
Methods:
The fetal heart samples were obtained from melatonin administrated RUPP rats.
Results:
Our results indicate that preeclampsia exacerbated by melatonin deficiency triggers hypoxic conditions, both mis/un-folded protein response, oxidative stress-induced DNA damage and apoptosis. Melatonin treatment provided significant therapeutic effects on fetal hearts via regulating all these stress response at cellular and molecular levels.
Conclusion:
Melatonin may be considered as a potential molecule for development of preventive strategies to reduce the PE induced risk of cardiovascular diseases in offspring.
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