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To Kill a Microglia: A Case for CSF1R Inhibitors
Kim N Green1, Joshua D Crapser1, Lindsay A Hohsfield1
1Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
Trends in Immunology
|August 15, 2020
Summary
Microglia, the brain's immune cells, play crucial roles in the central nervous system. Pharmacological CSF1R inhibitors offer versatile methods for studying these cells in health and disease.
Area of Science:
- Neuroscience
- Immunology
- Cell Biology
Background:
- Microglia are key immune cells in the central nervous system (CNS).
- Understanding microglial roles in CNS health and disease is crucial.
- Microglial depletion methods are essential tools for this research.
Purpose of the Study:
- To review and compare major microglial depletion methods.
- To evaluate the versatility and limitations of different techniques.
- To identify optimal methods for future microglial research.
Main Methods:
- Review of toxin-based, genetic, and pharmacological microglial depletion strategies.
- Analysis of methods based on depletion onset, duration, and off-target effects.
- Focus on Colony-Stimulating Factor 1 Receptor (CSF1R) inhibitors.
Main Results:
- Different depletion methods offer varying spatiotemporal control over microglial ablation.
- Toxin-based and genetic methods have specific limitations.
- Pharmacological CSF1R inhibitors provide extensive versatility.
Conclusions:
- Pharmacological CSF1R inhibitors are highly versatile for manipulating microglia.
- These inhibitors are ideal for future studies on microglial function in CNS conditions.
- Advanced microglial manipulation is key to understanding CNS health and disease.
