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Polyreactive Antibodies Bridge Immunity Particles to Pathogen

Henrique Machado1, Luisa M Figueiredo1

  • 1Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-048 Lisboa, Portugal.

Trends in Parasitology
|August 15, 2020
PubMed

Humans are protected from most African trypanosomes via high-density lipoproteins, known as trypanosome lytic factor (TLF). In humans, IgM antibodies are found associated with TLF. The recent work by Verdi et al. studied the origin of these antibodies and their binding partners, suggesting a new model for TLF uptake.

Keywords:
IgMantibodiesinnate immunitytrypanosome lytic factortrypanosomestrypanosomiasis

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