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Electrical antimicrobial susceptibility testing based on aptamer-functionalized capacitance sensor array for clinical

Kyo-Seok Lee1, Sun-Mi Lee2, Jeseung Oh3

  • 1Department of Physics, Yonsei University, Seoul, 03722, Republic of Korea.

Scientific Reports
|August 15, 2020
PubMed
Summary
This summary is machine-generated.

A new electrical antimicrobial susceptibility test (e-AST) delivers results in 6 hours, significantly faster than traditional methods. This rapid testing aids antimicrobial stewardship and improves patient outcomes for bacterial infections.

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Area of Science:

  • Biomedical Engineering
  • Clinical Microbiology
  • Diagnostic Technology

Background:

  • Timely antimicrobial susceptibility testing (AST) is crucial for effective bacterial infection treatment and preventing antibiotic misuse.
  • Conventional AST methods often exceed 16 hours, delaying critical treatment decisions.
  • There is a need for rapid AST solutions to improve patient care and combat antimicrobial resistance.

Purpose of the Study:

  • To develop and evaluate a novel electrical AST (e-AST) system for rapid susceptibility results.
  • To assess the performance of the e-AST system compared to standard broth microdilution.
  • To determine the potential of e-AST in supporting antimicrobial stewardship.

Main Methods:

  • Development of an e-AST system utilizing 60 aptamer-functionalized capacitance sensors.
  • Implementation of a pattern-matching algorithm for data analysis.
  • Validation of the e-AST system against broth microdilution using clinical isolates from septic patients.

Main Results:

  • The e-AST system provides results within 6 hours, a significant improvement over conventional methods.
  • Achieved a 97% categorical agreement with the reference broth microdilution method.
  • Reported minor error rates of 2.2%, major error of 0.38%, and very major error of 0.38% across 4,554 tests.

Conclusions:

  • The developed e-AST system offers a rapid and accurate alternative for antimicrobial susceptibility testing.
  • This technology has the potential to significantly aid antimicrobial stewardship programs.
  • Faster AST results are expected to lead to improved patient outcomes in managing bacterial infections.