Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Angiotensin-converting enzyme inhibitors.

H H Rotmensch1, P H Vlasses, R K Ferguson

  • 1Sackler School of Medicine, Tel-Aviv University, Israel.

The Medical Clinics of North America
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of amiodarone on theophylline pharmacokinetics in the rat.

Pharmaceutical research·2013
Same author

Potentially lethal interaction of cimetidine and morphine.

Canadian Medical Association journal·2010
Same author

Cascade genetic testing for mismatch repair gene mutations.

Familial cancer·2008
Same author

Clinical and economic outcomes of coronary angioplasty alone or in combination with stents in academic health centers: a retrospective database analysis.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2006
Same author

How do academic health centers value and encourage clinical research?

Academic medicine : journal of the Association of American Medical Colleges·2001
Same author

Wernicke-Korsakoff syndrome in head injury: a missed insult.

Alcohol and alcoholism (Oxford, Oxfordshire). Supplement·2001

Angiotensin-converting enzyme (ACE) inhibitors effectively treat hypertension and heart failure. These drugs offer favorable side effect profiles and improved patient well-being, leading to expected increased future acceptance.

Area of Science:

  • Pharmacology
  • Cardiovascular Medicine
  • Nephrology

Background:

  • Hypertension and congestive heart failure are significant cardiovascular conditions.
  • Effective blood pressure management is crucial for patient outcomes.
  • Angiotensin-converting enzyme (ACE) inhibitors represent a key therapeutic class.

Purpose of the Study:

  • To review the efficacy and tolerability of ACE inhibitors.
  • To compare the pharmacokinetic profiles of available ACE inhibitors.
  • To assess the benefits of ACE inhibitors in hypertension and heart failure.

Main Methods:

  • Review of existing clinical evidence and pharmacological data.
  • Comparison of hemodynamic, hormonal, and clinical effects.
  • Analysis of side effect profiles and patient-reported outcomes.

Related Experiment Videos

Main Results:

  • ACE inhibitors, with or without diuretics, effectively lower blood pressure in various hypertension grades.
  • They are beneficial as adjunctive therapy for congestive heart failure.
  • Captopril and enalapril show comparable efficacy and favorable side effect profiles, with differing pharmacokinetics (enalapril has slower onset and longer duration).

Conclusions:

  • ACE inhibitors offer significant advantages over other agents, including improved well-being.
  • Their favorable profile suggests increasing acceptance by patients and physicians.
  • Further research may explore long-term outcomes and broader applications.