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Updated: Dec 12, 2025

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
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miRNA-based biomarkers, therapies, and resistance in Cancer

Boxue He1,2, Zhenyu Zhao1,2, Qidong Cai1,2

  • 1Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

International Journal of Biological Sciences
|August 15, 2020
PubMed

Insights

MicroRNAs (miRNAs) are small molecules crucial for gene regulation, and their malfunction is linked to cancer. Research highlights their role in cancer progression, diagnosis, and therapy, offering new treatment avenues.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression.
  • miRNA dysregulation is associated with human diseases, particularly cancer.
  • Extensive research has explored the link between miRNAs and various cancers over the past two decades.

Purpose of the Study:

  • To review the current understanding of microRNAs in cancer.
  • To summarize their roles in cancer progression, immune response, and therapy resistance.
  • To discuss potential future prospects and clinical implications of miRNA research in oncology.

Main Methods:

  • Literature review of studies on microRNAs and cancer.
  • Analysis of miRNA functions in tumor development and progression.
  • Examination of miRNA-based diagnostic and therapeutic strategies.

Main Results:

  • miRNAs are involved in cancer progression, tumor immunity, and act as miRNA sponges.
  • Numerous miRNA biomarkers have been identified for cancer diagnosis and prognosis.
  • miRNA-based therapies and combination strategies show potential clinical benefits.
  • miRNAs play a role in cancer therapy resistance through complex regulatory mechanisms.

Conclusions:

  • MicroRNAs are significant players in cancer biology with broad clinical implications.
  • Understanding miRNA regulatory mechanisms is vital for improving cancer treatment and patient outcomes.
  • Further research into miRNAs holds promise for advancing cancer screening, diagnosis, and therapy.
Keywords:
CancerCancer therapy resistanceMicroRNAsmiRNA-based biomarkersmiRNA-based therapies

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