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Crosstalk Between the Hepatic and Hematopoietic Systems During Embryonic Development
Francisca Soares-da-Silva1,2,3,4,5,6, Márcia Peixoto1,2,3,4,5,6, Ana Cumano4,5,6
1Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Frontiers in Cell and Developmental Biology
|August 15, 2020
Summary
Hematopoietic stem cells (HSCs) are crucial for lifelong blood production. Understanding fetal liver development and its interaction with HSCs may improve cell therapies by enabling ex vivo expansion.
Area of Science:
- Developmental biology
- Hematopoiesis
- Stem cell biology
Background:
- Hematopoietic stem cells (HSCs) are essential for generating all blood lineages throughout life.
- HSC transplantation is a vital cell therapy but limited by the inability to expand HSCs ex vivo.
- HSCs reside in bone marrow in adults but expand in the fetal liver during embryonic development.
Purpose of the Study:
- To explore the concurrent establishment of fetal liver and hematopoietic systems.
- To evaluate the cross-modulation between these developing systems.
- To understand mechanisms regulating physiological HSC expansion for improved cell therapies.
Main Methods:
- This review synthesizes existing research on fetal liver development and hematopoiesis.
- It analyzes the composition dynamics of the fetal liver during embryonic development.
- It examines molecular networks governing HSC expansion.
Main Results:
- HSCs expand in the fetal liver, a transient embryonic hematopoietic site.
- The interplay between the developing hematopoietic and hepatic systems is not fully understood.
- Further insights into fetal liver composition and its impact on HSCs are needed.
Conclusions:
- Understanding the cross-modulation between fetal liver and hematopoietic development is crucial.
- Elucidating molecular networks regulating HSC expansion can enhance ex vivo expansion strategies.
- Improved ex vivo HSC expansion holds promise for advancing cell therapies.
Keywords:
cytokine signalingfetal hematopoiesisfetal liverfetal liver microenvironmenthematopoietic stem cell expansionhematopoietic stem cell nichehematopoietic stem cellsself-renewalMore Related Videos
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