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COVID-19 and the Kidneys: An Update

Claudia Benedetti1, Meryl Waldman2, Gianluigi Zaza3

  • 1Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Frontiers in Medicine
|August 15, 2020
PubMed

Insights

The new coronavirus disease (COVID-19) primarily affects adults, causing mild symptoms in most but severe respiratory and kidney damage in some. Research is ongoing to find effective treatments for this global health emergency.

Area of Science:

  • Infectious Diseases
  • Nephrology
  • Critical Care Medicine

Background:

  • The novel coronavirus disease 2019 (COVID-19) emerged as a global health crisis.
  • While often mild, COVID-19 can cause severe alveolar damage, respiratory failure, and fatalities.
  • Kidney damage, including acute kidney injury, has been observed in COVID-19 patients.

Purpose of the Study:

  • To investigate the impact of COVID-19 on patients with pre-existing kidney conditions.
  • To understand the pathogenesis of COVID-19, including viral injury, inflammation, and coagulation.
  • To identify potential therapeutic agents for COVID-19.

Main Methods:

  • Review of existing literature on COVID-19 pathogenesis and clinical manifestations.
  • Analysis of reported cases of kidney damage in COVID-19 patients.
  • Exploration of preliminary research on potential COVID-19 treatments.

Main Results:

  • COVID-19 predominantly affects individuals aged 30-79, with 81% experiencing mild illness.
  • Severe cases involve alveolar damage, respiratory failure (6.4% mortality), and potential kidney injury.
  • The effects on individuals with chronic kidney disease, transplant recipients, and hemodialysis patients remain unclear.

Conclusions:

  • COVID-19 poses a significant threat, causing diverse organ damage beyond the respiratory system.
  • Further research is crucial to elucidate COVID-19's impact on vulnerable kidney patient populations.
  • Several potential therapeutic agents are under investigation for COVID-19 treatment.

Keywords:
AKICOVID-19acute kidney injurydialysistransplant

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