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Chromium-catechin complex, synthesis and toxicity check using bacterial models.

Aafreen Fathima1, Verasundaram Manickavasagar Manikandamathavan2, Raghava Rao Jonnalagadda1

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Heliyon
|August 15, 2020
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Summary

This study synthesized a chromium-catechin complex and tested its toxicity in bacterial models. The complex showed mild inhibition against Bacillus subtilis, suggesting potential for future antidiabetic drug development.

Keywords:
BiomarkersChromium-catechin complexEcotoxicologyEnvironmental pollutionEnvironmental scienceEnvironmental toxicologyHexa-aquaMetalsMicrobiologyToxicology

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Area of Science:

  • Coordination Chemistry
  • Biochemistry
  • Toxicology

Background:

  • Chromium complexes are explored for therapeutic applications.
  • Catechins possess antioxidant and potential medicinal properties.
  • Investigating novel metal-ligand complexes for drug development is crucial.

Purpose of the Study:

  • To synthesize and characterize a chromium-catechin complex.
  • To evaluate the toxicity and biological activity of the complex using bacterial models.
  • To assess the potential of the chromium-catechin complex as an antidiabetic drug candidate.

Main Methods:

  • Synthesis of chromium-catechin complex.
  • Characterization using ESI Mass spectrometry, electronic spectroscopy, FT-IR, and cyclic voltammetry.
  • Toxicity studies on bacterial models (Bacillus subtilis, Escherichia coli) including growth profiling, inhibition studies, and Scanning Electron Microscopy (SEM) analysis.

Main Results:

  • The chromium-catechin complex exhibited mild inhibitory effects on Bacillus subtilis, primarily through oxidative damage and cell membrane targeting.
  • The complex supported the growth of Escherichia coli.
  • SEM analysis indicated slight morphological changes in Bacillus subtilis liposomes but not in Escherichia coli.

Conclusions:

  • Bacterial toxicity studies provide a rapid and resource-efficient method for preliminary assessment of novel drug candidates.
  • The chromium-catechin complex demonstrates differential effects on bacterial strains, with potential for further investigation.
  • Further toxicity studies in animal models are warranted to explore its potential as an antidiabetic agent.