Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid Digestion01:06

Lipid Digestion

97.9K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
97.9K
Lipid Absorption01:24

Lipid Absorption

2.2K
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
2.2K
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

114
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
114
Lipid Catabolism01:25

Lipid Catabolism

644
Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
644
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

398
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
398
Lipids as Anchors01:32

Lipids as Anchors

6.9K
In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative Assessment of Semi-Industrial Thermal and Non-Thermal Pasteurization Technologies for Red Globe Grape Juice.

Foods (Basel, Switzerland)·2026
Same author

Submicron-oleogel particles for enhanced oral delivery of hydrophobic compounds: <i>In vitro</i> and <i>in vivo</i> proof of concept.

Materials today. Bio·2025
Same author

Editor's note to 'harnessing the potential of human breast milk to boost intestinal permeability for nanoparticles and macromolecules' [journal of controlled release, 379 (2025) 768-785].

Journal of controlled release : official journal of the Controlled Release Society·2025
Same author

Safety Evaluation of Serendipity Berry Sweet Protein From Komagataella phaffii.

Journal of applied toxicology : JAT·2025
Same author

Potential of Process-Induced Modification of Potato Starch to Modulate Starch Digestibility and Levels of Resistant Starch Type III.

Foods (Basel, Switzerland)·2025
Same author

Strategic Considerations in Designing Food Solutions for Seniors.

Foods (Basel, Switzerland)·2025

Related Experiment Video

Updated: Dec 12, 2025

In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids
10:20

In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids

Published on: November 18, 2022

3.1K

Controlling lipid intestinal digestibility using various oil structuring mechanisms.

Areen Ashkar1, Jasmine Rosen-Kligvasser1, Uri Lesmes1,2

  • 1Faculty of Biotechnology and Food Engineering, Technion, Israel.

Food & Function
|August 15, 2020
PubMed
Summary
This summary is machine-generated.

Researchers controlled lipid hydrolysis in oleogels by combining ethyl cellulose (EC) and mono/di-glycerides (E471). Adjusting ratios tuned gel properties and digestion rates, offering insights for fat mimetic systems.

More Related Videos

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.4K
DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

48.3K

Related Experiment Videos

Last Updated: Dec 12, 2025

In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids
10:20

In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids

Published on: November 18, 2022

3.1K
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.4K
DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

48.3K

Area of Science:

  • Food Science and Technology
  • Materials Science
  • Biochemistry

Background:

  • Oleogels offer structured fat alternatives, but controlling their lipid hydrolysis and digestion profile remains a challenge.
  • Ethyl cellulose (EC) and mono/di-glycerides (E471) are common structuring agents with distinct properties.
  • Understanding the synergistic effects of combined structuring agents is crucial for designing functional oleogels.

Purpose of the Study:

  • To investigate the impact of combining ethyl cellulose (EC) and mono/di-glycerides (E471) on oleogel properties.
  • To determine how these combined structuring agents influence lipid hydrolysis and digestion kinetics.
  • To explore the potential for rational design of oleogels for controlled lipid release.

Main Methods:

  • Oleogels were formulated using combinations of EC (20 cP and 45 cP) and E471 at varying ratios.
  • Gelation profiles were analyzed using rheological measurements (G', G'').
  • Mechanical properties of the gels were assessed.
  • In vitro intestinal lipolysis was performed, and kinetics were analyzed using first-order models.

Main Results:

  • Combined E471 and EC formed dual gel networks, with EC providing a matrix for E471 crystallization.
  • Synergistic effects leading to harder gels were observed in E471:EC 20 cP mixtures, peaking at a 7:3 ratio.
  • Lipolysis rate and extent were modulated by the structuring agent composition, with higher rates observed for EC and lower rates for E471.
  • Lipolysis kinetics correlated with the oil state (liquid vs. solid) and network strength, which influenced lipase accessibility.

Conclusions:

  • The composition of structuring agents (EC and E471) significantly controls oleogel physical properties and lipid hydrolysis.
  • Synergistic interactions between EC and E471 can enhance gel strength.
  • Oleogel design offers a strategy to modulate lipid digestion and the release of hydrophobic components.