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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Total urinary polyphenols and longitudinal changes of bone properties. The InCHIANTI study.

A Di Iorio1, M Abate2, S Bandinelli3

  • 1Department of Medicine and Science of Aging, University Centre of Sports Medicine, University "G. d'Annunzio", Chieti, Italy. a.diiorio@unich.it.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|August 15, 2020
PubMed
Summary

Higher urinary total polyphenols (UTP), indicating greater polyphenol intake, were linked to faster bone deterioration over time. This study suggests increased polyphenol consumption may not aid osteoporosis prevention.

Keywords:
BoneBone-pQCTDietary polyphenolsLongitudinal studyUrinary polyphenols

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Area of Science:

  • Nutritional Science
  • Bone Biology
  • Gerontology

Background:

  • Polyphenols, from plant-based foods, possess antioxidant and anti-inflammatory properties.
  • These compounds are investigated for their potential role in osteoporosis prevention.
  • Urinary total polyphenols (UTP) serve as a biomarker for dietary polyphenol intake.

Purpose of the Study:

  • To investigate the association between UTP levels and longitudinal changes in bone properties.
  • To assess the impact of polyphenol intake on bone health over time in the InCHIANTI cohort.

Main Methods:

  • The InCHIANTI study included 956 participants providing 24-h urine samples for UTP assessment.
  • Bone properties (mass, diaphyseal design, material quality) were measured using peripheral quantitative computerized tomography (pQCT) of the tibia.
  • Mixed models analyzed the relationship between baseline UTP tertiles and changes in bone characteristics over a follow-up period (1998-2004).

Main Results:

  • Higher baseline UTP levels correlated with better bone mass, diaphyseal design, and material quality at the tibia.
  • Participants in higher UTP tertiles exhibited greater cortical bone area, mineral content, and thickness at baseline.
  • However, these same participants experienced accelerated deterioration of these bone parameters during the follow-up period.

Conclusions:

  • Dietary polyphenol intake, estimated by UTP and questionnaires, was associated with accelerated long-term bone health decline.
  • Findings do not support increasing polyphenol intake for osteoporosis prevention.
  • Further research is needed to clarify the complex relationship between polyphenols and bone metabolism.