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Interactions between invasive fungi and symbiotic bacteria

Fen Wang1, Caiyan Xin1, Jiexing Liu1

  • 1School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, People's Republic of China.

World Journal of Microbiology & Biotechnology
|August 15, 2020
PubMed

Insights

Drug-resistant invasive fungal infections are rising. Symbiotic bacteria interactions offer novel anti-fungal mechanisms, presenting a promising strategy against these challenging infections.

Area of Science:

  • Medical Mycology
  • Microbial Ecology
  • Infectious Diseases

Background:

  • Rising prevalence and mortality of invasive fungal infections (Candida, Aspergillus, Cryptococcus).
  • Increased antifungal drug resistance due to screening pressure poses a significant health challenge.
  • Emerging evidence links microbial community dynamics to infectious disease outcomes.

Purpose of the Study:

  • To review research on interactions between invasive fungi and symbiotic bacteria.
  • To focus on the anti-fungal mechanisms employed by symbiotic bacteria.
  • To propose novel strategies against drug-resistant fungal infections.

Main Methods:

  • Literature review of existing studies on fungal-bacterial interactions.
  • Analysis of reported anti-fungal mechanisms of symbiotic bacteria.
  • Synthesis of findings to identify therapeutic potential.

Main Results:

  • Invasive fungi and symbiotic bacteria exhibit complex interactions affecting fungal growth, morphology, and virulence.
  • Specific anti-fungal mechanisms of symbiotic bacteria are being elucidated.
  • Understanding these interactions provides insights into novel therapeutic targets.

Conclusions:

  • Symbiotic bacterial anti-fungal mechanisms represent a promising avenue for combating drug-resistant invasive fungal infections.
  • Further research into the intricate mechanisms of these interactions is crucial for developing new treatment strategies.
  • Targeting fungal-bacterial crosstalk could revolutionize the management of invasive fungal diseases.
Keywords:
Dynamic balanceInteractionInvasive fungiSymbiotic bacteria

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