Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor*
Paula Morales1, Gemma Navarro2, Marc Gómez-Autet3
1Medicinal Chemistry Institute, Spanish Research Council, Madrid, Spain.
Abstract:
Single chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB2 receptor. These compounds selectively target CB2 versus CB1 receptors. Their binding mode was studied by molecular dynamic simulations and site-directed mutagenesis.
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