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Amir Erez¹, Tommy A Byrd², Michael Vennettilli²

¹Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.

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|August 16, 2020

Summary

Cellular communication relies on molecule exchange, but intracellular dynamics

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Area of Science:

Systems biology
Information theory
Cellular dynamics

Background:

Cells exchange molecules to share information.
Influence of intracellular dynamics on cell-to-cell communication is not fully understood.

Purpose of the Study:

Investigate how intracellular dynamics affect information exchange between two interacting cells.
Analyze the relationship between cellular states, critical points, and mutual information.

Main Methods:

Utilized information theory to model two interacting cells with internal feedback.
Analyzed the emergence of collective critical points and mutual information peaks.

Main Results:

Cell-to-cell molecule exchange creates a collective two-cell critical point.
Mutual information between cells is maximized at this critical point.
An information-correlation time trade-off exists, with information scaling logarithmically with correlation time.

Conclusions:

The correlation time can serve as a proxy for mutual information in cellular systems.
Cellular communication dynamics are governed by a strict information-correlation time trade-off.