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A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
Published on: December 10, 2012
Merge-split Markov chain Monte Carlo for community detection
1Department of Network and Data Science, Central European University, H-1051 Budapest, Hungary; ISI Foundation, Via Chisola 5, 10126 Torino, Italy; and Department of Mathematical Sciences, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.
Abstract:
We present a Markov chain Monte Carlo scheme based on merges and splits of groups that is capable of efficiently sampling from the posterior distribution of network partitions, defined according to the stochastic block model (SBM). We demonstrate how schemes based on the move of single nodes between groups systematically fail at correctly sampling from the posterior distribution even on small networks, and how our merge-split approach behaves significantly better, and improves the mixing time of the Markov chain by several orders of magnitude in typical cases. We also show how the scheme can be straightforwardly extended to nested versions of the SBM, yielding asymptotically exact samples of hierarchical network partitions.
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