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Nodular sclerosing Hodgkin's disease with giant Reed-Sternberg cells.
H F Frierson1, D J Innes, C E Hess
1Department of Pathology, University of Virginia Medical Center, Charlottesville 22908.
Southern Medical Journal
|March 1, 1988
Summary
A rare case of Hodgkin's disease in a 70-year-old woman presented with unusual giant Reed-Sternberg cells. Effective chemotherapy led to a complete remission lasting over seven years.
Area of Science:
- Oncology
- Pathology
- Immunohistochemistry
Background:
- Hodgkin's disease is a malignant lymphoma characterized by the presence of Reed-Sternberg cells.
- Diagnosis can be challenging, especially in elderly patients or when atypical cell morphology is present.
Observation:
- A 70-year-old female patient presented with extensive lymphadenopathy and pleomorphic, giant Reed-Sternberg-like cells on lymph node biopsy.
- Immunohistochemical analysis revealed positivity for Leu-M1, alpha 1-antitrypsin, S-100 protein, kappa, and lambda light chains.
Findings:
- The patient was diagnosed with pathologic stage IV-B Hodgkin's disease based on clinical presentation and biopsy findings.
- Treatment with five cycles of chemotherapy resulted in a complete remission.
Implications:
- This case highlights the importance of comprehensive diagnostic workup, including immunohistochemistry, for challenging Hodgkin's disease presentations.
- The successful treatment outcome in an elderly patient with advanced-stage disease suggests potential efficacy of standard chemotherapy regimens.
- Long-term remission in this case provides valuable data on prognostic factors and treatment response in elderly Hodgkin's lymphoma patients.