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Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism
Published on: January 12, 2019
Perioperative observations of different bypass modes of a right coronary system based on instantaneous blood flow
Zhou Zhao1, Chun Fu2, Li-Xue Zhang1
1Cardiac Surgery Department, Peking University People's Hospital, Beijing, 100044, China.
Insights
Sequential coronary artery bypass grafting (CABG) in the right coronary artery system shows improved blood flow and better graft patency compared to single grafts. This strategy is crucial for managing increasing coronary atherosclerotic heart disease (CAD) in aging populations.
Area of Science:
- Cardiovascular Surgery
- Vascular Grafting
- Cardiac Hemodynamics
Background:
- Coronary atherosclerotic heart disease (CAD) incidence and mortality are rising with China's aging population.
- Coronary artery bypass grafting (CABG) is a critical intervention for CAD.
- Optimizing CABG strategies for the right coronary artery system is essential.
Purpose of the Study:
- To analyze CABG strategies in the right coronary artery.
- To compare hemodynamic characteristics of sequential versus single grafts.
- To evaluate graft patency rates one week post-operation.
Main Methods:
- 242 patients undergoing right coronary artery bypass grafting were studied.
- Trans-thoracic flow measurement (TTFM) assessed graft blood flow (Q) and pulsatility index (PI).
- Coronary computed tomography (CT) evaluated graft patency one week post-surgery.
Main Results:
- Sequential grafts demonstrated significantly higher instantaneous blood flow than single grafts (P < 0.01).
- Diastolic flow (DF) was significantly better in sequential grafts of the right coronary system compared to non-sequential grafts (P < 0.001).
- Graft occlusion or stenosis was significantly lower in sequential grafts (1 case) versus single grafts (11 cases) (P < 0.01).
Conclusions:
- Sequential grafting in the right coronary artery system, particularly to the posterior descending artery (PDA), offers superior hemodynamic performance.
- Sequential grafts exhibit improved patency rates compared to single grafts one week post-CABG.
- This strategy is effective in managing coronary atherosclerotic heart disease in the studied population.
Background:
With the ageing of China's population, the incidence and mortality of coronary atherosclerotic heart disease (CAD) is increasing year by year, which brings a heavy burden to the family and society [1]. We aimed to analyse the strategy of coronary artery bypass grafting (CABG) in the right coronary artery and to compare the haemodynamic characteristics of the sequential grafts with those of single grafts and to observe the patency rate of those grafts for 1 week after the operation.
Methods:
A total of 242 patients (178 men, mean age 62.6 ± 8.8 years) underwent right coronary artery bypass grafting in our hospital from October 2016 to January 2019. The blood flow (Q, ml/min), pulsatility index (PI) and related parameters of the grafts were measured and recorded by TTFM during the CABG. The patency of the grafts was evaluated by coronary computed tomography (CT) for 1 week after the operation.
Results:
The most common material used for the graft in the right coronary system of CABG is the greater saphenous vein (92.3%), followed by the radial artery (5.5%) and the internal mammary artery (1.9%). The highest frequency target of the right coronary artery is the posterior descending artery (PDA) (47.6%), followed by the right main coronary artery (RCA) (29.1%) and the posterior branch of the left ventricle (PL) (23.3%). The proportion of single grafts was the highest for the right coronary artery in CABG (178 cases, 67.9%), followed by a graft of the PDA-PL (42 cases, 16.0%) and other sequential grafts among the different coronary artery systems (including the system of the left anterior descending artery (LAD) and the left circumflex (LCX)). Whether there were sequential grafts of the PDA-PL or other sequential grafts among the different systems of the coronary artery, the instantaneous flow of a group of sequential grafts was higher than that of a single graft, and the difference had statistical significance (P < 0.01). However, there were no significant differences in the flow between the groups of sequential grafts (P = 0.410). Diastolic flow (DF) in the group of sequential grafts of the right coronary system was better than that in the non-sequential group (P < 0.001), and the difference had statistical significance. There was no significant difference between the DF of the groups of the other system of sequential grafts and that of the right coronary sequential grafts. Coronary artery CT suggested that there were 11 cases of poorly developing grafts or stenosis and occlusion a week after the operation, and those phenomenon mainly occurred in the group with a single graft. There was only one case that was occluded in the group of other systems of sequential grafts, and statistically significant differences existed between the two groups (P < 0.01).
Conclusions:
In our centre, the most common form of CABG in the right coronary artery system is a non-sequential vein bridge to the PDA. Whether there are sequential grafts of the PDA-PL or other sequential grafts among the different coronary artery systems, the instantaneous flow of a group of sequential grafts is higher than that of a single graft. DF in the group of sequential grafts of the right coronary system was better than that in the non-sequential group.
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