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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Updated: Dec 12, 2025

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
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Epigenetic alterations in aging tooth and the reprogramming potential.

Mahshid Hodjat1, Fazlullah Khan2, Khandakar A S M Saadat3

  • 1Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Ageing Research Reviews
|August 16, 2020
PubMed
Summary
This summary is machine-generated.

Oral aging impairs dental tissue function and healing. Epigenetic modifications, influenced by nutrients and microbiota, offer potential targets for anti-aging interventions in dentistry.

Keywords:
AgingDNA methylationEpigeneticsPeriodontiumTooth

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Area of Science:

  • Gerontology
  • Dental Science
  • Epigenetics

Background:

  • Aging significantly alters tooth structure, function, and repair capacity.
  • Cellular changes include reduced cementocyte viability and stem cell regenerative potential.
  • Impaired osteogenic and odontogenic differentiation of progenitor cells contributes to oral aging.

Purpose of the Study:

  • To explore the molecular mechanisms of dental aging, focusing on epigenetics.
  • To investigate the role of nutri-epigenetics and microbiota in modulating dental aging.
  • To identify potential anti-aging interventions targeting epigenetic modifications in oral tissues.

Main Methods:

  • Review of current literature on aging, epigenetics, and dental tissues.
  • Analysis of studies on nutrients, bioactive compounds, and microbiota effects on epigenetic markers.
  • Evaluation of the link between external stimuli and age-related epigenetic changes.

Main Results:

  • Epigenetic alterations are a key molecular mechanism in dental aging.
  • Nutrients and bioactive compounds can modulate epigenetic machinery, showing promise for dental aging.
  • The human microbiota plays a role in aging and can be targeted for interventions.

Conclusions:

  • Epigenetic modifications are central to dental aging.
  • Nutri-epigenetics and microbiota modulation represent promising avenues for anti-aging strategies in dentistry.
  • Targeting reversible epigenetic markers offers potential to mitigate age-related dental tissue deterioration.