Reciprocal interactions between sodium appetite and need-free sugar intake.
B M Santos1, R B David2, C A F Andrade1
1Department of Physiology and Pathology, Dentistry School, UNESP, Araraquara, SP, Brazil.
Appetite
|August 16, 2020
Summary
A rapid sodium appetite protocol cross-sensitized sucrose intake in rats, suggesting glutamate receptor plasticity mediates interactions between sodium and sugar cravings.
Area of Science:
- Neuroscience
- Behavioral Neuroscience
- Physiology
Background:
- Behavioral sensitization is observed in both sodium appetite and need-free intake.
- Previous research indicated a slow-onset sodium appetite protocol cross-sensitized need-free sucrose intake in rats.
- This prior finding suggested a link between sodium depletion and subsequent sugar consumption.
Purpose of the Study:
- To determine if a rapid-onset sodium appetite protocol (furosemide/captopril) cross-sensitizes sucrose intake.
- To investigate interactions between sensitized need-free sodium intake and need-free sucrose intake.
- To examine if MK-801, a glutamate NMDA receptor antagonist, inhibits this cross-sensitization.
Main Methods:
- Rats received repeated furosemide/captopril or vehicle treatments.
- Sucrose intake was measured in hydrated and fed conditions after treatments.
- MK-801 was administered to assess its effect on cross-sensitization and sodium intake.
Main Results:
- The rapid-onset furosemide/captopril protocol successfully cross-sensitized sucrose intake in sucrose-naïve rats.
- MK-801 treatment appeared to prevent the cross-sensitization of sucrose consumption.
- Unexpectedly, sucrose intake tests reduced sensitized need-free sodium intake, but MK-801 facilitated a rebound.
Conclusions:
- Plasticity in glutamatergic mechanisms likely mediates reciprocal interactions between sodium appetite and sucrose intake.
- The findings suggest a complex interplay between systems regulating salt and sugar consumption.
- NMDA receptor activity is implicated in the cross-sensitization phenomenon.
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