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Related Concept Videos

Induced Electric Fields: Applications01:27

Induced Electric Fields: Applications

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An important distinction exists between the electric field induced by a changing magnetic field and the electrostatic field produced by a fixed charge distribution. Specifically, the induced electric field is nonconservative because it does not work in moving a charge over a closed path. In contrast, the electrostatic field is conservative and does no net work over a closed path. Hence, electric potential can be associated with the electrostatic field but not the induced field. The following...
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Induced Electric Fields01:23

Induced Electric Fields

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The fact that emfs are induced in circuits implies that work is being done on the conduction electrons in the wires. What can possibly be the source of this work? We know that it’s neither a battery nor a magnetic field, as a battery does not have to be present in a circuit where current is induced, and magnetic fields never do any work on moving charges. The source of the work is in fact an electric field that is induced in the wires. For example, if a stationary conductor is placed in a...
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Electric Field01:16

Electric Field

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Consider two point charges, each exerting Coulomb force on the other. It is possible to describe the Coulomb interaction via an intermediate step by defining a new physical quantity called the electric field.
In the new picture, imagine that the first charge sets up an electric field independent of all other charges in the universe. When another charge comes in its vicinity, the second charge experiences an electric force depending on the electric field at that point. The source charge does not...
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Electric Field Lines01:25

Electric Field Lines

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The three-dimensional representation of the electric field of a positive point charge requires tracing the electric field vectors, whose lengths decrease as the square of their distance from the charge and which point away from the charge at each point. This vector field is no doubt challenging to visualize. The visualization of electric fields becomes quickly intractable as the number of charges increases.
The solution to this problem is to use electric field lines, which are not vectors but...
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Equipotential Surfaces and Field Lines01:29

Equipotential Surfaces and Field Lines

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Electric potential can be pictorially represented as a three-dimensional surface. On such a surface, the electric potential is constant everywhere. The equipotential surface is always perpendicular to the electric field lines, and while it is three-dimensional, it can be treated as an equipotential line in a two-dimensional case. These equipotential lines are also always perpendicular to electric field lines. The term equipotential is often used as a noun, referring to an equipotential line or...
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Finding Electric Potential From Electric Field01:13

Finding Electric Potential From Electric Field

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For a system of charges, it is easy to calculate the system's potential because potential is a scalar quantity. However, in some instances where calculating the electric field is more straightforward than finding the potential, the electric field is used to calculate the system's potential. For a positive charge, the electric field is radially outward, and the potential is positive at any finite distance from the positive charge. In such an electric field, the motion away from the...
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EView: An electric field visualization web platform for electroporation-based therapies.

Enric Perera-Bel1, Carlos Yagüe1, Borja Mercadal1

  • 1BCN MedTech, Department of Information and Communication Technologies, Universitat Pompeu Fabra, c/ Roc Boronat 138 Edifici Tanger 55.119, 08018 Barcelona, Spain.

Computer Methods and Programs in Biomedicine
|August 16, 2020
PubMed
Summary

EView is a free web platform that models electric field distribution for electroporation treatments. It helps predict treatment volumes by visualizing electric fields based on electrode placement and tissue properties, aiding both experts and non-experts.

Keywords:
Electric field visualizationElectrochemotherapyElectroporationIrreversible electroporationModelingSimulationTreatment planningWeb platform

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Area of Science:

  • Biomedical Engineering
  • Medical Physics

Background:

  • Electroporation increases cell membrane permeability to ions and macromolecules using high electric fields.
  • Accurate prediction of treatment volume in electroporation is challenging due to complex dependencies on electrode configuration, applied voltage, and tissue conductivity.
  • Current methods struggle to preoperatively infer treatment efficacy based on electrode placement and tissue properties.

Purpose of the Study:

  • To develop EView, a web-based platform for estimating electric field distribution in electroporation.
  • To provide a tool for visualizing electric fields overlaid on 3D medical images for arbitrary electrode configurations.
  • To aid in the preoperative planning and understanding of electroporation-based treatments.

Main Methods:

  • A client-server architecture was implemented for user-friendly electrode configuration via a web browser.
  • The finite element method (FEM) was employed on a dedicated server to solve for electric field distribution in a 3D volume.
  • A homogeneous tissue model was used, incorporating the non-linear dependence of tissue conductivity on the electric field.

Main Results:

  • The EView platform rapidly computes electric field distributions for various electrode and tissue configurations.
  • Simulations achieved high accuracy, comparable to state-of-the-art finite element solvers (Dice coefficient of 98.3% ± 0.4%).
  • The server demonstrated reliability and responsiveness during high load testing, with simulations completing in under 40 minutes.

Conclusions:

  • EView offers a free, accessible tool for modeling electric field distribution in electroporation.
  • The platform empowers both expert and non-expert users to rapidly assess electric field patterns for diverse electrode setups.
  • This tool facilitates better understanding and planning of electroporation treatments by providing rapid and accurate electric field estimations.