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Updated: Dec 12, 2025
Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
Published on: September 9, 2022
Association between TNFA, IL10 and IL18 promoter gene variants and cognitive functions in patients with
Anastasiya Georgieva Trenova1, Lyuba Dineva Miteva2, Spaska Angelova Stanilova2
1Department of Neurology, Medical University of Plovdiv, Plovdiv 4000, Bulgaria.
Objectives:
To investigate the relationship between TNFA-308G > A, IL10-1082A > G, IL18-607C > A, and cognitive functioning in relapsing-remitting multiple sclerosis (RRMS).
Results:
In the patients' group: AG genotype of TNFA-308G > A was associated with higher serum tumor necrosis factor-alpha (TNF-alpha) than GG genotype, and higher TNF-alpha levels correlated with poorer results on Symbol Digit Modalities Test; CC genotype of IL18-607C > A was related to lower score on Isaacs test, compared to AC variant; AA genotype of IL10-1082A > G was associated with abnormally low results on Paced Auditory Series Addition Test.
Conclusions:
TNFA-308G > A, IL10-1082A > G and IL18-607C > A gene variants may be associated with impaired cognitive functions in RRMS patients.
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