A comprehensive review of dual-energy and multi-spectral computed tomography

This review will provide a brief introduction to the development of the first Computed Tomography (CT) scan, from the beginnings of x-ray imaging to the first functional CT system introduced by Godfrey Houndsfield. The principles behind photon interactions and the methods by which they can be leveraged to generate dual-energy or multi-spectral CT images are discussed. The clinical applications of these methodologies are investigated, showing the immense potential for dual-energy or multi-spectral CT to change the fields of in-vivo and non-destructive imaging for quantitative analysis of tissues and materials. Lastly the current trends of research for dual-energy and multi-spectral CT are covered, showing that the majority of instrument development is focused on photon counting detectors for mutli-spectral CT and that clinical research is dominated by validation studies for the implementation of dual-energy and multi-spectral CT.