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Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

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Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
128
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

119
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

711
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
711
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems01:22

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

88
Body:Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug...
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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
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Solid lipid nanoparticles for enhanced oral absorption: A review.

Eman Salah1, Mahmoud M Abouelfetouh2, Yuanhu Pan3

  • 1National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, People's Republic of China; Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt.

Colloids and Surfaces. B, Biointerfaces
|August 16, 2020
PubMed
Summary

Solid lipid nanoparticles (SLNs) offer a promising solution for enhancing oral drug absorption and stability. Further research into their gastrointestinal transport mechanisms is crucial for optimizing therapeutic formulations.

Keywords:
In vitro modelOral drug deliverySolid lipid nanoparticleTransport mechanism

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Area of Science:

  • Pharmaceutical Sciences
  • Nanotechnology
  • Drug Delivery

Background:

  • Oral drug delivery faces challenges with poor drug solubility, permeability, and degradation.
  • Solid lipid nanoparticles (SLNs) are innovative nanocarriers designed to overcome these limitations.
  • SLNs utilize transcellular and paracellular pathways for absorption, improving drug bioavailability.

Purpose of the Study:

  • To review recent advancements in using SLNs for oral drug delivery.
  • To highlight SLNs' mechanisms for overcoming gastrointestinal barriers.
  • To discuss novel in vitro methods for studying SLN absorption and transport.

Main Methods:

  • Review of current literature on SLNs for oral drug delivery.
  • Analysis of SLN absorption and transport mechanisms across gastrointestinal hurdles.
  • Examination of in vitro protocols for investigating transmembrane absorption and kinetics.

Main Results:

  • SLNs demonstrate potential in enhancing oral absorption of poorly absorbed drugs.
  • Various in vitro models are being developed to study SLN interactions with the gastrointestinal tract.
  • Understanding SLN transport mechanisms is key to improving drug bioavailability.

Conclusions:

  • SLNs represent a significant advancement in oral therapeutic formulations.
  • Further investigation into SLN-intestinal mucosa interactions at cellular and molecular levels is needed.
  • Optimizing SLN absorption efficiency and understanding their correlation with drug bioavailability are critical future research directions.