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Coronavirus disease 2019 (COVID-19): Immunological approaches and emerging pharmacologic treatments

Pedram Goodarzi1, Farzad Mahdavi2, Rasoul Mirzaei3

  • 1Faculty of Pharmacy, Iran University of Medical Sciences, Tehran, Iran.

International Immunopharmacology
|August 16, 2020
PubMed

Insights

Current COVID-19 treatments lack proven effectiveness. This review covers emerging immunological and antiviral strategies to combat the SARS-CoV-2 virus, addressing gaps in understanding its pathogenesis.

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes the global COVID-19 pandemic.
  • Existing therapies for COVID-19 are not definitively effective.
  • Understanding SARS-CoV-2 pathogenesis remains incomplete.

Purpose of the Study:

  • To review current knowledge on SARS-CoV-2.
  • To highlight emerging immunological approaches for COVID-19 treatment.
  • To discuss novel antiviral strategies against SARS-CoV-2.

Main Methods:

  • Literature review of recent studies on SARS-CoV-2.
  • Analysis of immunological procedures and drug targets.
  • Synthesis of information on antiviral strategies.

Main Results:

  • Numerous potential immunological targets identified.
  • Several promising antiviral drug candidates are emerging.
  • Gaps in understanding COVID-19 pathogenesis persist.

Conclusions:

  • Continued research into SARS-CoV-2 virology is crucial.
  • Development of effective COVID-19 therapies requires further investigation.
  • Immunological and antiviral strategies offer potential for future treatments.
Keywords:
Antiviral strategiesCOVID-19Drug targetsImmunological approachesSARS-CoV-2

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