A near-infrared fluorescent probe for hydrogen polysulfides detection with a large Stokes shift

Due to the crucial biological roles of hydrogen polysulfides (H₂S_n) in living systems, the selective determination of H₂S_n is essential. In this work, we reported a turn-on fluorescent probe, JSI-Sn, for H₂S_n with high sensitivity and good selectivity. Probe JSI-Sn displayed a near-infrared emission (λ_max^Em = 701 nm) and a large Stokes shift (123 nm) in the presence of H₂S_n in solution. Using probe JSI-Sn as an indispensable tool, the monitoring of intracellular H₂S_n in living cells and zebrafish were realized.